A comparison of the efficacy of amoxicillin and nasal irrigation in treatment of acute sinusitis in children / 소아과

PURPOSE: The efficacy of antibiotic therapy for acute sinusitis is controversial. This study aimed to compare the efficacies of amoxicillin with nasal irrigation and nasal irrigation alone for acute sinusitis in children. METHODS: This randomized, double-blind, controlled study included 80 children aged 4-15 years with a clinical presentation of acute sinusitis. Patients were randomly assigned to receive either amoxicillin (80 mg/kg/day) in 3 divided doses orally for 14 days with saline nasal irrigation (for 5 days) and 0.25% phenylephrine (for 2 days) or the same treatment without amoxicillin. Clinical improvements in their initial symptoms were assessed on days 3, 14, 21, and 28. RESULTS: On day 3, patients in the amoxicillin with nasal irrigation group showed significant clinical improvement (P=0.001), but there was no significant difference in the degree of improvement between the amoxicillin with nasal irrigation and nasal irrigation alone groups during follow-up (P>0.05). In addition, no significant differences were seen in age, sex, and degree of improvement between groups (P>0.05). CONCLUSION: High-dose amoxicillin with saline nasal irrigation relieved acute sinusitis symptoms faster and more often than saline nasal irrigation alone. However, antibiotic treatment for acute sinusitis confers only a small therapeutic benefit over nasal irrigation.

analgesic effect of ethanolic extract of tanacetum parthenium in acetic acid model

Different Tanacetum species have been widely used in traditional medicine as a remedy for the pain and inflammation since ancient times. Because of the few studies conducted on the mechanism of Tanacetum parthenium [TP], this study has been conducted to determine the effects of TP on pain relief and its action mechanism. In this experimental study, 100 male mice [25-35 g] were randomly grouped into receivers of distilled water, morphine [0.5 mg/kg], ibuprofen [100 mg/kg], different doses of the extract including 10, 20, 30 and 40 mg/kg of the extract. In order to study the pain relief effect of this herb, two groups were also received naloxon [0.5 mg/kg] and naloxon together with the 40 mg/kg of the extract. Animals were injected with 0.9% acetic acid for visceral pain induction. 15 minutes after each injection antinociceptive effects were recorded by counting the number of writhes for 30 minutes. Achieved data were analyzed by SPSS statistical software, Kruskal-Wallis and Dunn post hoc test. 40 mg/kg of the extract of TP caused a significant reduction in the pain response. Group receiving a dose of 40 mg/kg extract had higher antinociceptive effects than the group receiving ibuprofen [p<0.001] but it didn't have any significant difference with the group receiving morphine. Group receiving naloxone had a statistical significant difference with the group receiving 40 mg/kg extract with naloxone and the group receiving 40 mg/kg extract [p<0.001]. Antinociceptive activity of TP extract is due to the activation of opioid system, however further studies are needed to be conducted for finding out the suitable position or the role of the antispasmodic effect of TP

Selenium and leptin levels in febrile seizure: a case-control study in children / 소아과

PURPOSE: Febrile seizures (FS) are seizures that occur between the age of 6 and 60 months, but its pathophysiology still is not fully understood. There is limited information about the correlation between levels of selenium and leptin with FS. This study aimed to determine the relationship between serum levels of selenium and leptin in children with FS. METHODS: This case-control study was conducted in a University Hospital in Shahrekord, Iran, in 2011. The serum levels of selenium and leptin of 25 children with simple febrile seizure (case group) were compared with 25 febrile children without seizure (control group) in acute phase and after three months. The levels of serum selenium and leptin were measured by flame atomic absorption spectrophotometer and enzyme-linked immunosorbent assay method, respectively. RESULTS: In acute phase, the mean serum level of selenium in case and control groups were 95.88+/-42.55 and 113.25+/-54.43 microg/dL, respectively, and difference was not significant (P=0.415), but after three months, this level had a significant increase in both groups (P<0.001). In acute phase, the mean serum leptin level in case and control groups were 0.94+/-0.5 and 0.98+/-0.84 ng/mL, respectively, but difference was not significant (P=0.405). After three months, serum leptin level had no significant change in both groups (P=0.882). CONCLUSION: These observations suggest that serum levels of selenium and leptin have not specific relation with FS but overllay is lower, however, further study is recommended. Also selenium level in stress and acute phase was significantly lower than recovery phase.